At 8:36 a.m. ET, Dow e-minis were down 163 points, or 0.61%, S&P 500 e-minis were down 24.5 points, or 0.76%, and Nasdaq 100 e-minis were down 139 points, or 1.28%.
The pan-European STOXX 600 index slipped 0.1%, failing to match Asian and Wall Street gains , France's CAC 40 fell 0.7% after the country set a new record of daily COVID-19 infections.
Versus the dollar, sterling was up 0.3% at $1.2784 by 0823 GMT, after hitting a two-month low of $1.2676 on Wednesday . Against the euro, sterling was also up 0.4% at 91.24 pence. , after hitting a one-week high of 91.13 on Thursday.
Japan's benchmark Nikkei 225 edged up 0.6% to 23,214.38. Australia's S&P/ASX 200 gained 1.5% to 5,964.90, while South Korea's Kospi added 0.6% at 2,285.09. Hong Kong's Hang Seng gave up earlier gains, sinking 0.7% to 23,146.61. The Shanghai Composite index fell 0.4% to 3,209.85.
Shares rose in India but fell in Taiwan and Thailand.
Spot gold was flat at $1,868.29 per ounce by 0627 GMT. But prices are down over 4% for the week pressured by a broadly stronger greenback. US gold futures were down 0.3% to $1,871.
Brent crude was down 4 cents at $41.90 a barrel by 0635 GMT, while US West Texas Intermediate (WTI) crude dropped 8 cents to $40.23.
An index of stocks across the globe fell on Thursday and the dollar rose for a fifth session running on lingering concern about another economic hit from the coronavirus pandemic.
The Indian stock market witnessed a bloodbath on Thursday, in line with the global selloff, with the BSE Sensex losing 1,114.82 points. Post Thursday’s selloff, Sensex lost 2,292 points in the last four sessions. This was the sixth consecutive session of loss for the Indian indices.