James Anderson reacts a after teammate Jos Buttler dropped a catch during the fourth day at the Ageas Bowl on Monday. AP
Anderson, who started the fourth day's play in the third Test with 598 wickets, induced an edge from Shan Masood but wicketkeeper Jos Buttler floored a routine chance.
It was the fourth dropped catch in 37 balls off Anderson and the closest either he, or England, came to a wicket in the session in Southampton.
The swing specialist, so effective in English conditions, bowled five overs for a miserly nine runs before captain Joe Root replaced him with express fast bowler Jofra Archer.
Pakistan were 41-0 after being made to follow on when rain stopped play at 1121 GMT and the players took an early lunch.
Dark clouds loom over as groundsmen pull on the covers after rain stopped play on the fourth day. AP
Masood was 13 not out and Abid Ali 22 not out, with Pakistan still 269 runs adrift of England's mammoth first innings 583-8 declared.
A huge downpour during the interval then threatened to keep the players off the field for several hours.
With more rain forecast for Tuesday and no certainty as to when England will next play a Test due to the coronavirus pandemic, Anderson could be left stranded on 598 Test wickets for some time yet.
England are 1-0 up in the three-match contest and will win their first Test series against Pakistan in a decade if they avoid defeat at the Ageas Bowl.
No paceman has yet reached the landmark figure of 600 Test wickets, with the only bowlers ahead of the 38-year-old Anderson in the all-time list a trio of retired spinners — Sri Lanka's Muttiah Muralitharan (800), Australia's Shane Warne (708) and India's Anil Kumble (619).
Anderson started the day in sight of joining the select group after taking 5-56— his 29th five-wicket haul in 156 Tests — during Pakistan's first-innings 273.
He might even have reached the landmark late on Sunday had not three catches been dropped off his bowling with the new ball.
And there was more frustration for Anderson when left-hander Masood, on three, edged an intended drive outside off-stump only for the ball to hit Buttler on the thigh as he failed to get his gloves to a chance far less difficult than several catches he held on Sunday.
England batsman Ollie Pope injured his shoulder chasing a ball to the boundary and was replaced by James Bracey, with the substitute fielder summing up the hosts' morning when his needless shy at the stumps led to four overthrows.
Pakistan resumed on Monday a huge 310 runs behind a total built on Zak Crawley's 267 and Buttler's 152. The pair shared an England fifth-wicket record stand of 359.
Pakistan captain Azhar Ali's superb 141 not out kept England at bay longer than looked likely after his side collapsed to 75-5 on Sunday.
Azhar found an ally in Mohammad Rizwan, with the wicketkeeper making 53 in a sixth-wicket stand of 138 with his skipper.
Next month international cricket is set to resume for the first time since the outbreak as England host the West Indies in a three-Test series staged behind closed doors.
Crawley brought up an 80-ball fifty off the last ball of the session when, tempted to drive after Pakistan reinforced the slip cordon, he stylishly struck Shaheen Afridi down the ground to long-off for the seventh four of his innings.
The 22-year-old Crawley was the seventh England batsman to turn his maiden Test hundred into a double century and the first since Kent predecessor Rob Key did so against the West Indies at Lord's in 2004.
Team Manager Joxean Matxin Fernandez (Spa) will lead the squad alongside Sports Directors Andrej Hauptman (Slo), Simone Pedrazzini (Swi) and Marco Marcato (Ita).
Indian women will play a three ODI series in the captaincy of the Harmanpreet Kaur against Sri Lanka’s 19-member squad, which is being led by Chamari Athapaththu.
A dominant England has swept New Zealand 3-0 in the Test series with an aggressive seven-wicket victory in the third and final Test match on Monday.