Into the final of the Copa del Rey and with a comfortable 11-point lead at the top of La Liga, Barca coach Ernesto Valverde is expected to give a number of fringe players a chance when they visit bottom side Huesca on Saturday.
The five-time European champions will face either Liverpool or Porto in the last four in their first appearance at the stage of the competition since 2015.
Lionel Messi finished with a bloody nose and swollen cheek but Barcelona left unscathed, with one foot in the semi-finals and Manchester United hoping for another Champions League miracle.
Four years have passed since Lionel Messi last reached a Champions League semi-final and his drought has become a source of unease for Barcelona ahead of their latest attempt on Tuesday.
Lionel Messi has a history of terrorising Manchester United but Ole Gunnar Solskjaer believes it is not impossible to stop the Barcelona star inflicting more damage in Wednesday’s Champions League quarter-final.
Luis Suarez's 12th minute back-post header was deflected past David de Gea by United left-back Shaw.
Barcelona might have their eighth title in 11 years all-but sewn up but, with six games left to play, La Liga is far from finished.
Lionel Messi and Luis Suarez might be the deadliest attack in Europe but Barcelona’s success in the Champions League could rest on their increasingly mean defence.
Zinedine Zidane said on Wednesday La Liga will be Real Madrid’s top priority next season after they were mathematically ruled out of the title race with five games left.