The pan-European STOXX 600 index fell 1.9%, on track for its biggest one-day drop in a month, pushing it to a weekly loss for the first time in four weeks.
The benchmark Nikkei 225 index fell 1.06 percent or 238.48 points to end at 22,290.81. It inched down 0.07 percent over the week. The broader Topix index dropped 1.42 percent or 22.04 points to 1,535.20. It lost 1.10 percent over the week.
The benchmark Nikkei 225 index was down 0.76 per cent, or 175.14 points, at 22,770.36, while the broader Topix index fell 0.66 per cent, or 10.45 points, to 1,579.06.
MSCI's broadest index of Asia-Pacific shares outside Japan advanced 0.4%, paring some of its 2% losses the previous day, while Nikkei slid 0.3% on concerns about rising virus infections in Tokyo.
The FTSE 350 travel and leisure index, which was tracking its worst year in a decade with a 40% fall, was down 2.3% to its lowest in nearly a month. IAG fell to the bottom of London's bluechip index, while TUI was the worst performer on the mid-caps and On The Beach underperformed the small caps.
The key Nikkei 225 index dropped 0.26 per cent, or 58.47 points, to end at 22,657.38, extending its losing streak to the third trading day. The broader Topix lost 0.48 per cent, or 7.57 points, to 1,569.12.
The key Nikkei 225 index fell 1.15 per cent, or 260.27 points, to 22,397.11, extending its losing streak for a fourth trading day. The broader Topix index dropped 1.28 per cent, or 20.08 points, to 1,549.04.
Asian stock markets were mostly higher Tuesday after Wall Street rose on a flurry of corporate deals and China's economic activity improved. Shanghai, Hong Kong and Seoul gained, while Tokyo retreated.
The benchmark Nikkei 225 index fell 0.44 per cent, or 104.41 points, to 23,454.89 while the broader Topix index lost 0.62 per cent, or 10.26 points, to 1,640.84.