Environment Canada issued a weather warning just before 6 pm local time, saying a funnel cloud had been spotted at the Gatineau airport, moving eastward.
Authorities have urged citizens to stay away from the valleys and open areas due to unstable weather.
"Calhoun City was hit hard tonight," the county sheriff, Greg Pollan, said on Facebook. "Light poles have been snapped off. Trees in a few homes. Trees on vehicles. Damage to several businesses."
Authorities estimated there were at least 600 injuries so far, and Little Rock police were transporting people to hospitals as there were not enough ambulances to respond, according to local media outlet KTHV.
A tornado touched down in Palm Beach Gardens, Florida, on Saturday as a powerful storm system brought intense rain and powerful winds to the state, overturning cars, damaging homes and snapping tree branches.
Singer Taylor swift has taken action after a string of tornadoes destroyed parts of Tennessee.
At least 30 people were injured in Nashville, the state capital, and least 48 buildings were destroyed, with many more damaged.
A vicious storm tore through the Kansas City area, spawning tornadoes that downed trees and power lines, damaged homes and injured at least a dozen people in the latest barrage of severe weather that saw tornado warnings as far east as New York City.
Severe damage, including fatalities, occurred after a likely tornado struck in El Reno, Oklahoma, on Saturday night, according to local police and media reports.