Alexander Zverev returns a shot to Tommy Paul at the BNP Paribas Open tennis tournament in Indian Wells, California, on Sunday. AP
After dropping a first set in which Paul mercilessly punished his second serve, Germany's Zverev levelled the match with the only break of the second set in the 10th game.
After holding his serve to love three times and breaking Paul in the sixth game of the third Zverev appeared to be heading for victory.
But the German immediately served four double faults to hand the break back and Paul dominated the tiebreak with the same aggression he showed in the opening set.
"I played a really high level today," said Paul, who notched the biggest win of his career. "I knew how I wanted to play him, so I came out and executed it well.
"It got kind of crazy there in the second set, and I got lucky a little bit in the end, but I played well when it came down to the breaker, so I'm pretty happy with my performance."
Zverev was playing his first tournament since he was disqualified from the Mexico Open in Acapulco after losing his temper and repeatedly smashing his racquet into the umpire's chair.
The 24-year-old Tokyo Olympic gold medallist was fined $40,000 for verbal abuse and unsportsmanlike conduct. A further $25,000 fine and an eight-week ban were suspended provided he does not incur a further code violation for 12 months.
In other men's second-round action, seventh-seeded Andrey Rublev pushed his ATP winning streak to 10 matches, shaking off a slow start to beat Dominik Koepfer 7-5, 6-4.
Andrey Rublev hits a shot during a victory Dominik Koepfer in a second round match. Reuters
Rublev, on the rise after titles in Marseille and Dubai this year, was 4-2 down before breaking 51st-ranked Koepfer twice to pocket the first set.
He finished with 32 winners against the German and won 11 of 15 points at the net to put the match away.
Sixth-seeded Italian Matteo Berrettini also advanced, holding on for a 6-3, 4-6, 6-4 victory over Danish qualifier Holger Rune.
But ninth-seeded Canadian Felix Auger-Aliassime bowed out, falling 7-6 (7/4), 6-7 (4/7), 6-3 to Botic van de Zandschulp of the Netherlands.
Alexander Bublik, the 31st seed, sent former world number one Andy Murray packing with a 7-6 (11/9), 6-3 win over the three-time Grand Slam champion.
Bublik, coming off his first career ATP title at Montpellier in February, beat Murray for the first time in three career meetings.
There was more disappointment for Murray's British compatriot Emma Raducanu, who was beaten in the third round by Croatian Petra Martic 6-7 (3/7), 6-4, 7-5.
The 19-year-old Briton, who stormed to an unlikely US Open title as a qualifier last year, served for the match at 5-4 in the third.
But the 13th seed couldn't muster a match point and lost the next three games, a string of forehand errors spelling the end of her challenge in a final loss of serve.
It was the latest setback for Raducanu, who was ousted in the second round of the Australian Open in January and suffered a hip injury at Guadalajara last month.
Martic, ranked 79th in the world, notched her first win over a top-20 player in more than two years.
"I really wanted it so bad," Martic said "I'm just happy I stayed calm when I was not playing so good. Because I think it was up and down for both sides."
Third-seeded Iga Swiatek of Poland, the highest-ranked player left in the women's field, struggled early but dominated late in a 6-7 (3/7), 6-2, 6-1 victory over Denmark's Clara Tauson.
Iga Swiatek hits a shot during her third round match against Clara Tauson. Reuters
Former world number one Simona Halep crashed Coco Gauff's 18th birthday celebrations, beating the US youngster 6-3, 6-4.
Halep, the 2015 Indian Wells WTA champion, coped beautifully with blustery winds, her 11 winners almost matching her 12 unforced errors while the aggressive Gauff's unforced errors soared to 33.
Halep said the she was pleased with her performance in the tricky conditions. "I think I played a smart tennis," said the Romanian, who saved all four break points she faced.
World ranked 139 Tauson saw off Switzerland's Viktorija Golubic 6-4, 6-1 to guarantee a top 100 debut on Monday. Tauson was playing in just her third main draw and with Sunday's win confirmed her status as one of the sport's in-form players.
The 22-year-old Belarusian tennis star Aryna Sabalenka finished her 2020 campaign with triumphs in Ostrava and Linz and will be one of the favourites for the delayed Australian Open next month.
Ons jabeur, a beacon of encouragement and hope for every aspiring female in the Arab world playing tennis, will be one of the star attractions when the Dubai Duty Free Tennis Championships gets underway next month.
Her victory in the Women's singles badminton at the Commonwealth took her to completing a hat-trick of medals at the Games with a win over Michelle Li of Canada in the women's singles final in Birmingham.
She picked up her first victory since the 2021 French Open on Monday, beating Nuria Parrizas-Diaz 6-3, 6-4 at the women’s National Bank Open.
The six-time defending champions showed their opponents no mercy in sweltering conditions on the final day of sporting action in Birmingham.