Lisbon: Cristiano Ronaldo missed his third consecutive training session on Friday with Portugal coach Fernando Santos pessimistic he will recover from a toe infection in time for the start of their UEFA Nations League title defence against Croatia.

The Juventus star, who has 99 goals in 164 international matches, is with the squad preparing for the match in Porto on Saturday but has not trained since Tuesday.

“I am very doubtful that by tomorrow (Saturday) he will be 100 percent OK,” Santos told a press conference.

He said Ronaldo, 35, was continuing “gym work” having trained “very well” at the start of the week.

“Then suddenly (on Wednesday) one of his toes was red, as if he’d been stung by a bee,” Santos reported, adding that Ronaldo was on a course of antibiotics after seeing a dermatologist.

“Now we have to wait. With an injury you can have an idea of how the recovery is going to take. With an infection you never know.”

The five-time Ballon d’Or winner has not played since early August when Juventus were knocked out of the Champions League by Lyon.

He scored 37 goals in all competitions last season, a record for a Juve player, and insists he remains ambitious, laying out his season ‘goals’ on Instagram last week.

“Victories. Commitment. Dedication. Professionalism. With all my strength and with the precious help from my teammates and all of the Juventus staff, we work once again to conquer Italy, Europe and the World!” he wrote.

After Croatia, Portugal face Sweden in Solna on Tuesday, with their group also containing world champions France.

Aside from Ronaldo both Portugal and Croatia will be without other star players.

While the Portuguese football federation said midfielder Renato Sanches, has been released from the squad for unspecified medical reasons, Croatia have excused Luka Modric and Ivan Rakitic from duties against Portugal and for a World Cup final rematch with France on Tuesday.

Agence France-Presse