While Kieron Pollard played his last T20 in India last November, Sunil Narine’s last appearance in a T20 came against England almost two years ago.
The Caribbean side scored 311 for six in their 50 overs in Leeds and although the Afghans put up a brave fight, they ultimately went down by 23 runs.
Only 7.3 overs were bowled at Hampshire's Rose Bowl on Monday after West Indies skipper Jason Holder won the toss and sent South Africa in to bat.
The two-time champions, who are unbeaten in their six outings so far, including a washed-out game, fielded an unchanged side after their narrow victory against Afghanistan.
The 23-time Slam winner returns to tennis next week at the inaugural Top Seed Open WTA event in Lexington, Kentucky, relaunching her season after a six-month hiatus caused by the COVID-19 pandemic.
England were struggling in pursuit of a victory target of 277 after collapsing to 117-5 on the fourth day. But man-of-the-match Woakes, who had helped drag England back into this contest with 2-11 in just five overs late on Friday, and fellow World Cup winner Jos Buttler turned the tide with a stand of 139.
Chelsea winger Christian Pulisic faces six weeks out with a right hamstring injury that could see him miss the start of the English Premier League.