Delta, about 250 miles (400 km) south of Cameron, Louisiana with maximum sustained winds of 120 miles per hour (195 km/h) at present, could slowly weaken as it approaches the northern Gulf coast later on Friday.
The incident comes amid fresh debate over US gun controls, stoked by an incident last week where a gunman shot eight people dead and injured several others at a FedEx facility in Indianapolis before taking his own life.
Authorities ramped up evacuations, airlines cancelled flights and flood gates slammed shut as the National Hurricane Center forecast the strengthening storm would reach hurricane status on Saturday.
Authorities warned of heavy rain and possible tornadoes throughout Saturday as major storm Barry buffeted Louisiana, though there were few indications of widespread flooding.
The two-engine Piper Cheyenne crashed in the city of Lafayette about a mile from the regional airport where the flight began, Federal Aviation Administration spokesman Tony Molinaro said.
Nearly 1,800 households in trailers provided directly by FEMA are unable to return yet to homes damaged or destroyed by hurricanes Laura and Delta in 2020, according to a news release last week.
The bodies had not been found as of Friday afternoon, according to the official. Representatives of the Federal Aviation Administration and the National Transportation Safety Board were traveling to the area to investigate.
More than 70 million Americans have cast ballots in the US presidential election, more than half the total turnout of the 2016 election with one week to go until Election Day, according to a Tuesday tally from the US Elections Project.
The shooting Friday night was captured on video, and the state ACLU condemned what it described as a "horrific and deadly incident of police violence against a Black person.” Both the ACLU and the Southern Poverty Law Center quickly called for an investigation.