London's benchmark FTSE 100 index dropped 0.5 percent to 6,152.82 points. The Paris CAC 40 index retreated 0.6 percent to 5,010.03 and Frankfurt's DAX 30 shed 0.3 percent to 12,961.12.
The pan-European STOXX 600 index was flat, while travel and leisure stocks shed the most among sectors with a 2.4% fall.
The pan-European STOXX 600 index rose 0.5% by 0716 GMT, holding ground after its worst session in three months. The technology sector, which has outperformed this year, rose 1.5%, while healthcare stocks were up 0.6%.
The pan-European STOXX 600 rose 1.3%, with Germany's DAX, London's FTSE 100 and France's CAC 40 gaining between 1.6% and 2.0%.
MSCI's broadest index of Asia-Pacific shares outside Japan rose 0.3%, Japan's Nikkei returned from a two-day holiday to slip 0.4%. Hong Kong and Shanghai remain steady.
Tokyo's Nikkei 225 edged 0.1% higher to 23,475.53 while the Hang Seng in Hong Kong lost 0.2%, to 24,682.78. South Korea's Kospi gave up 0.4% to 2,433.41 and the S&P/ASX 200 in Sydney jumped 1% to 5,952.00. The Shanghai Composite index slipped 0.4% to 3,282.34.
The pan-European STOXX 600 index inched 0.3% higher, extending a winning run this week. London's blue-chip shares were dragged lower by a weakness in the banking sector. A bright spot in the market was a 26.4% surge in shares of the Hut Group, the first major British initial public offering in seven years.
The pan-European STOXX 600 dropped 1.1% by 0710 GMT, on course to break its four-day winning streak.
The benchmark Nikkei 225 index was down 0.67 per cent, or 156.16 points, at 23,319.37 at the close, while the broader Topix index ended down 0.36 per cent, or 5.95 points, at 1,638.40.