VIDEO: Israel hit by missiles as Iran retaliates for strikes on nuclear sites

An Israeli military official says dozens of incoming missiles have been detected.

A thick plume of smoke billowed over the coastal Israeli city of Tel Aviv on Friday after Iranian missile fire, an AFP journalist reported, following a wave of Israeli attacks on Iran. The smoke towered over the city's skyscrapers as blasts echoed across the city, the journalist said.

Iran's supreme leader Ayatollah Ali Khamenei said Friday that Israel's deadly attacks on his country will 'bring it to ruin', vowing retaliation. 'The armed forces of the Islamic republic will inflict heavy blows upon this malevolent enemy,' Khamenei said in a televised speech, adding that the consequences of the Israeli attack 'will bring it to ruin'.

Air raid sirens have sounded across Israel as Iranian missiles struck the country in retaliation for deadly Israeli attacks on nuclear sites and military leaders. 

The rumble of explosions could be heard throughout Jerusalem on Friday, and Israeli TV stations showed plumes of smoke rising in Tel Aviv after an apparent missile strike.

There were no immediate reports of casualties.

The army said dozens of missiles were launched, and the army has ordered residents across the country to move into bomb shelters.

Israel launched a wave of strikes across Iran that targeted its nuclear program and military sites, killing at least three top military officers and raising the prospect of an all-out war between the two bitter Middle East adversaries.

It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran's rapidly advancing nuclear program.

For years, Israel had threatened such a strike and successive American administrations had sought to prevent it, fearing it would ignite a wider conflict across the Middle East and possibly be ineffective at destroying Iran's dispersed and hardened nuclear program. __