US Secretary of State Antony Blinken gestures as he arrives in Tel Aviv, Israel, on Monday. Reuters

US Secretary of State Antony Blinken was due to meet Israeli leaders on Tuesday in his quest to prevent the Gaza conflict from growing into a regional conflagration, as the Israeli military said its fight against Hamas would continue all year.

Blinken arrived in Tel Aviv late on Monday to brief Israeli officials on his two days of talks with Arab leaders on ending the war.

He also said he would press Israeli Prime Minister Benjamin Netanyahu's government "on the absolute imperative to do more to protect civilians and to do more to make sure that humanitarian assistance is getting into the hands of those who need it".

The Israeli offensive has killed more than 23,000 Palestinians, destroyed much of Gaza and displaced most of the population of 2.3 million, creating a worsening humanitarian crisis.

In the latest sign that the war may be spreading, Israel killed a top commander of Hamas' ally Hezbollah in south Lebanon on Monday, sources familiar with the group's operations said.

Sources with direct knowledge of the matter told Reuters Israel is also carrying out an unprecedented wave of deadly strikes in Syria targeting cargo trucks, infrastructure and people involved in Iran's weapons lifeline to its proxies in the region.

Antony Blinken (centre) walks on the tarmac at Al Ula airport in Saudi Arabia as he departs for Tel Aviv. AFP

Israeli Defence Minister Yoav Gallant told the Wall Street Journal his country was determined to end Hamas' rule of Gaza and deter other Iran-backed adversaries.

But Israel has come under growing pressure from the United States, its closest ally, and Arab leaders to scale back the assault.

US President Joe Biden, confronted on Monday by protesters shouting "ceasefire now" while visiting an historic Black church in South Carolina, said he had been "quietly" working to encourage Israel to ease its attacks and "significantly get out of Gaza".

Israeli officials have said the operation is entering a new phase of more targeted warfare, but there was no respite in the fighting on Monday.

Reuters