Activists and local emergency teams have decried the UN's slow response to the quake in rebel-held areas.

Rare survivors were pulled from the debris eight days after the 7.8-magnitude quake struck Syria and Turkey, but the focus has switched from rescue to providing food and shelter to millions in need.

A caravan of 11 United Nations trucks entered Syria through the re-opened Bab Al Salama border point, after Damascus agreed to let the world body use the crossing for aid.

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Before the earthquake struck, almost all the crucial humanitarian aid for the more than four million people living in rebel-controlled areas of northwest Syria was being delivered through just one crossing.

The trucks were loaded with essential humanitarian assistance, including shelter materials, mattresses, blankets and carpets, Paul Dillon, a spokesman for the UN's International Organization for Migration (IOM), told the media.

Millions of people across the region are struggling for survival.

Activists and local emergency teams have decried the UN's slow response to the quake in rebel-held areas, contrasting it with the planeloads of humanitarian aid delivered to government-controlled airports.

The United States, which refuses ties with Syrian President Bashar Al Assad, called on both the government and rebels to work to allow in aid.

"Everyone should put aside their agendas and affiliations in service of one pursuit and one pursuit only, and that's addressing the humanitarian emergency — the humanitarian nightmare — that's unfolding in parts of northwest Syria," State Department spokesman Ned Price told reporters in Washington.

The UN also launched an appeal for $397 million to cover three months of "life-saving relief" for victims in Syria and said it was close to a similar plan for Turkey.

"Millions of people across the region are struggling for survival, homeless and in freezing temperatures," UN Secretary-General Antonio Guterres said.

Agence France-Presse