People sit surrounded by belongings following floods due to heavy rains, in Las Tejerias, Venezuela. Reuters

Houses and businesses were destroyed in the Saturday night deluge, which left the town of Las Tejerias covered with mud and debris, including felled trees, household items and mangled cars.

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"We are seeing very significant damage here, human losses," Vice President Delcy Rodriguez told local media at the scene.

Interior Minister Remigio Ceballos said at least 25 people had died in the disaster as he gave an updated toll on government television VTV late Sunday.

Residents help rescuers to dig up mud from destroyed homes as they search for victims in Las Tejerias. AFP

"Unfortunately so far we have 25 people who were recovered dead," he said. "We also have 52 missing," he said, adding that search efforts were continuing.

Dozens of people have died in recent months in the crisis-hit South American nation as a result of historically high levels of rain.

"The village is lost. Las Tejerias is lost," 55-year-old resident Carmen Melendez, who has lived her whole life in the town 50 kilometers (30 miles) from the capital, Caracas, told the media.

Around a thousand people had joined the rescue efforts, Interior and Justice Minister Remigio Ceballos told AFP, as he worked at the site.

Residents dug through the remains of battered homes looking for loved ones, while search teams arrived with dogs hoping to find survivors trapped in the rubble.

Local residents stand outside their flooded homes in Las Tejerias, Venezuela, on Sunday. AP

A butcher shop that had closed due to the pandemic and which was due to reopen Monday was buried in muddy sediment that caked the refrigerators and everything else inside.

"We were waiting for the meat to be shipped in -- to start after two years closed," said Ramon Arvelo, one of the workers who was helping remove mud.

"I never thought that something of this magnitude could happen; it's a really big deal," said Loryis Verenzuela, 50, as she looked out at the devastation through tears.

Agence France-Presse