At least 70 people have been killed and 13 went missing across the country in flash floods and landslides this year.
The latest calamity occurred in Achham district, about 450 km (281 miles) west of the capital city of Kathmandu.
Flash floods and landslides are a common occurrence in the mountainous terrain of the Himalayan nation especially during the annual monsoon rains between June and September.
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At least 70 people have been killed and 13 went missing across the country in flash floods and landslides this year, according to official data.
Volunteers, police and military rescuers were looking for people missing in Achham. In the neighbouring Kailali district, authorities recovered a body of a fisherman who had been swept away in the overflowing Geta river. Yagya Raj Joshi, an official in Kailali said about 1,500 people displaced because of the floods were sheltered in public buildings.
Local media broadcasted images of swathes of farms inundated by flood waters, a destroyed suspension bridge and villagers wading through chest deep water.
Landslides are common in mountainous Nepal during the monsoon season that usually ends in September.
Rescuers found the bodies of two children, a mother with her baby and another woman on Thursday in Shuicheng county, Guizhou province, according to state broadcaster CCTV, citing an investigation.
Heavy rains since Thursday have hit several districts in Nepal, especially in the country's eastern region and the southern plains, affecting thousands.
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New Zealand's GeoNet monitoring agency said the epicentre was 33 kilometres (21 miles) below the earth's surface. There was no immediate tsunami warning and no reports of damage on the New Zealand mainland.