Peruvian President Pedro Castillo's sister-in-law Yenifer Paredes attends as a guest a congressional audit to investigate Castillo and his wife in Lima. AFP

Castillo himself is the subject of five criminal investigations, including for graft, and has survived two impeachment attempts since taking office in July last year.

Images broadcast on several television channels showed agents entering Castillo's home in the rural, northern Cajamarca region on Wednesday.

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This came just hours after an unprecedented raid on Tuesday at the presidential palace in Lima to execute a warrant for the detention of Castillo's sister-in-law Yenifer Paredes.

But while agents left Castillo's house empty-handed, Paredes's lawyer Jose Dionisio later told RPP radio station that his client had taken investigators "by surprise" by turning up at the prosecutor's office and handing herself in.

"We are inside the prosecutor's office," Dionisio said.

Canal N Police officers raid the private home of Peru's President Pedro Castillo in Chugur, Peru, on Wednesday. AFP

The prosecutor's office did not confirm a raid had taken place but Castillo had said at a public event in Lima on Wednesday that "they have just entered my home."

Castillo, a 52-year-old rural school teacher and trade unionist, unexpectedly took power from Peru's traditional political elite in elections last year.

He has come under non-stop fire from his right-wing political rivals, and is also in the cross-hairs of the attorney general's office investigating claims including public tender corruption and that Castillo plagiarised his university thesis.

Opinion polls show that three-quarters of Peruvians disapprove of his management of the country, which has seen three prime ministers and seven interior ministers come and go in just over a year.

Paredes, 26, lives with Castillo and his wife, whom she reportedly views as "parents."

She is the fourth person in the presidential entourage to be investigated for alleged corruption, and also faces money laundering charges.

The others include a nephew who served as an adviser, a former transport minister — both fugitives from justice — and Castillo's former presidential secretary.

The Court of Justice said in a statement that Tuesday's raid on the presidential palace was to execute a judicial search warrant for Paredes.

Agence France0Presse