A man sits at the debris of a destroyed house after a missile strike in Slovyansk, Donbas, on Wednesday. AFP
The industrial hub of Severodonetsk has become a key target for Moscow, and the local governor said that 80 per cent of the city was now under Russian control.
"Street fighting continues," said Lugansk regional governor Sergiy Gaiday on Telegram, pledging Ukrainian forces "will fight for Severodonetsk until the end".
Ukraine stopped Russia from seizing Kyiv after its February invasion but the campaign in the east has had a high cost, with President Volodymyr Zelensky reportedly saying that up to 100 Ukrainian soldiers are dying daily.
A woman looks for belongings in the ruble of a house after a strike in Slovyansk on Wednesday. AFP
"The most difficult situation is in the Lugansk region, where the enemy is trying to displace our units from their positions," said Valeriy Zaluzhnyi, the commander in chief of Ukraine's armed forces, according to a statement from the military.
"The enemy has a decisive advantage in artillery," Zaluzhnyi told France's top general, Thierry Burkhard, in a phone call, adding he want his units to be equipped with weapons of the type used by military alliance NATO.
"It will save the lives of our people".
Ukrainian forces received a boost this week when US President Joe Biden announced that more advanced rocket systems were on the way.
The new weapon is the Himars multiple launch rocket system, or MLRS, a mobile unit that can simultaneously launch multiple precision-guided missiles up to 80 kilometres (50 miles) away.
They are the centrepiece of a $700 million package unveiled Wednesday that also includes air-surveillance radar, more Javelin short-range anti-tank rockets, artillery ammunition, helicopters, vehicles and spare parts.
But analysts caution the new rockets are unlikely to suddenly turn the tables — not least because Ukrainian troops need time to learn how to use them effectively.
Several European leaders have made efforts to show solidarity with the battle-scarred nation. Zelensky thanked the leaders of Britain and Austria for their visits Saturday to Kyiv, Ukraine's capital, and pledges of further support.
Governor Dmytro Zhyvytskyy posted photographs of the charred shell of a four-story building and rescuers searching rubble. In a later Facebook post, he said many Russian soldiers and some local residents also were killed during the fighting on Sunday.
Kathy Lueders, who heads the agency's human spaceflight program, told reporters on a call that operations on the research platform were proceeding "nominally" and "we're not getting any indications at a working level that our counterparts are not committed."
Asad Kaleem, an executive producer at ARY, said that the action means that 4,000 employees at the TV are now without work. He pleaded with the government to reverse its decision and bring the hugely popular ARY back on air.
The cabinet shake-up, which was approved by parliament in an emergency session, affected 13 portfolios, including health, education, culture, local development and irrigation ministries.
Other infrastructure was also damaged when gusts battered the Medusa Festival, a huge electronic music festival held over six days in the east coast town of Cullera.