An antiviral pill from Pfizer has been shown to reduce the risk of hospitalisation from COVID-19 by 90%. AP

President Joe Biden declared Tuesday that "it's time for Americans to get back to work” as he announced new efforts to allow people to return to normal activities safely after two years of pandemic disruptions.

The Biden administration will announce on Wednesday a National COVID-19 Preparedness Plan mapping out how "to move forward safely and get back to our more normal routines," the White House said.

Biden used his State of the Union address to announce that his administration was launching a "test-to-treat” initiative to provide free antiviral pills at pharmacies to those who test positive for the virus.

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He also highlighted the progress made on the pandemic since last year, with a dramatic reduction in cases, readily-available vaccines and tests, and new therapeutics soon becoming more accessible.

"Tonight, I can say we are moving forward safely, back to more normal routines,” Biden said. "It’s time for Americans to get back to work and fill our great downtowns again.”

A lab technician visually inspects Paxlovid tablet samples in Freiburg, Germany. AP

His comments come ahead of the White House release of a new "National COVID-19 Preparedness Plan” on Wednesday. The White House said it would be "a roadmap that will enable us to move forward safely, and sustain and build on the progress we’ve made over the past 13 months.”

In his remarks Tuesday, Biden said that in addition to starting the new antiviral initiative, his administration would allow people in the US to order another round of free tests from the government.

An antiviral pill from Pfizer has been shown to reduce the risk of hospitalisation from COVID-19 by 90%. By the end of the month, the administration says, 1 million pills will be available, with double that ready for use in April.

A White House official said the "test-to-treat” plan will initially roll out in hundreds of pharmacies across the country, including CVS, Walgreens, and Kroger locations. Those who test positive at the sites will be able to obtain the antiviral pills on the spot for immediate use.

Biden said that starting next week, the administration would make available four more free tests to US households through COVIDTests.gov, which has sent more than 270 million free tests to nearly 70 million households since it launched in mid-January.