People gather around a damaged building. File/AFP
One resident said at least 12 people were killed in the raid that took place around midnight in a densely populated area near the border with Turkey, where tens of thousands of displaced Syrians live in makeshift camps or overcrowded housing.
There was no immediate reports of any militant being killed, but residents said they heard heavy gunfire during the operation, indicating resistance to the raid.
The US State Department and the spokesperson for the coalition forces in northern Syria did not respond to requests for comment.
Charles Lister, senior fellow with the Washington-based Middle East Institute, said he had spoken to residents who said the operation lasted more than two hours.
"Clearly they wanted whoever it was alive," Lister said.
"This looks like the biggest of this type of operation" since the Baghdadi raid, he said.
Daesh leader Abu Bakr Al Baghdadi died in a US special operations raid in northwest Syria in 2019.
A man and a young girl walk on rubble. File/AFP
Residents and rebel sources said several helicopters landed near Atmeh in the province of Idlib, the last big enclave held by insurgents fighting Syrian President Bashar Al Assad, and explosions were heard near the home of a foreign militant.
The militant who was the suspected targeted was with his family at the time of the raid, said a rebel official who declined to be named.
One resident said several people were killed in the raid, while another said rescuers pulled out at least 12 bodies from the rubble of a multi-storey building, including children and women.
Witnesses said the raid had ended as aircraft believed to be choppers had left the site, but unidentified reconnaissance planes were still hovering in the area.
The rebel official said security from Hayat Tahrir Al Sham, the main rebel group that controls parts of northwest Syria, hurried to the location after the raid.
The northwest of Syria — Idlib province and a belt of territory around it — is mostly held by Hyat Tahrir Al Sham, the former Nusra Front, which was part of al Qaeda until 2016.
Several foreign militants figures who split from the group have set up the Huras Al Din (Guardians of Religion) group, designated as a foreign terrorist organisation, which has in recent years been the target of coalition strikes.
For years, the US military has launched mostly drones to kill top Al Qaeda operatives in northern Syria, where the militant group became active during Syria’s over decade-long civil war.
US-led coalition operations against remnants of Daesh sleeper cells are more frequent in northeast Syria held by Kurdish-led Syrian Democratic Forces.
Opposition war monitor the Syrian Observatory for Human Rights and activist collective Deir Ezzor 24 said the airstrikes targeted the Ayash Camp run by the Fatimiyoun group.
The village lies in Syria's last major rebel bastion of Idlib, which is dominated by the Hayat Tahrir Al Sham (HTS) group, led by a former Al Qaeda affiliate, and its rebel allies.
CENTCOM described the militants as facilitators, a logistician, and an "associate" of the militant group and said they were captured a day earlier. A civilian sustained "minor injuries" and was taken to a medical facility, CENTCOM said in a statement.
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Sheikh Abdullah Bin Zayed Al Nahyan expressed the UAE’s eagerness and commitment to supporting all efforts to maintain and enhance relations and bilateral cooperation in meetings with several heads of state participating in UNGA 78.
In the UAE’s statement, Al Hashimy pointed out the importance of maintaining an international order based on respect for the sovereignty, independence, and territorial integrity of states.