The ministry said the landmark was passed on Friday, beating the country's previous daily record of 9.2 million.
India on Friday, for the first time, administered more than 10 million Covid-19 jabs in a single day, under its nationwide mass vaccination drive against Covid-19.
Authorities said on Saturday that this is the highest-ever vaccination achieved in a single day since the start of the vaccination drive, as the South Asian giant bolsters its defences for a predicted new surge.
The health ministry said the landmark was passed on Friday, beating the country's previous daily record of 9.2 million.
In another significant achievement, India's Covid-19 vaccination coverage has crossed the 620,000,000 crore landmark and presently stands at 621,706,882, as per the provisional report of the Health Ministry.
A woman gets a vaccine jab from a health worker.
Prime Minister Narendra Modi hailed the milestone as a "momentous feat" for the nation of 1.3 billion people.
"Kudos to those getting vaccinated and those making the vaccination drive a success," he said on Twitter.
Health Minister Mansukh Mandaviya said: "Sabka Sath, Sabka Vikas, Sabka Vishwas and Sabka Prayas — This is the same effort by which the country has crossed the figure of more than 10 million vaccines in a day. The tireless work of health workers and PM Modi's determination to #SabkoVaccineMuftVaccine is paying off."
India's daily infection count has dropped dramatically since the devastating surge in April-May which overwhelmed its creaking health infrastructure.
Almost all restrictions on movement and activity have been lifted even though experts have warned of a new wave hitting as early as next month as the festival season starts.
In a separate development, India has also crossed the landmark milestone of administering at least one dose of Covid vaccine to 50 per cent of its adult population.
The United States now advises against travelling to India, even for those fully vaccinated, while Britain has added India to its "red list". Hong Kong and New Zealand have banned flights.
The latest health ministry data reports 314,835 new cases of the novel coronavirus over the previous 24 hours, the world's largest one-day rise in case numbers, a grim reminder of the threat still posed by the virus. Deaths rose by a record 2,104.
Daily infections, which surpassed 100,000 for the first time on Monday, have now exceeded that mark three times, the biggest daily rises in the world.
India plans to vaccinate 300 million people in the first half of 2021. Shots could start getting distributed as early as next week. Prime Minister Narendra Modi reviewed the preparedness for COVID-19 vaccination on Saturday, it said.
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