Vials and medical syringe are seen in front of AstraZeneca logo in this illustration. File photo/Reuters
AstraZeneca said on Monday its vaccine for the novel coronavirus could be around 90% effective without any serious side effects, the latest drugmaker to unveil positive interim data in a scientific race to curb a global pandemic.
The vaccine developed by Oxford University was 90% effective in preventing COVID-19 when it was administered as a half dose followed by a full dose at least one month apart, according to data from the late-stage trials in Britain and Brazil.
Another dosing regimen showed 62% efficacy when given as two full doses at least one month apart and the combined analysis from both dosing regimens resulted in an average efficacy of 70%. All results were statistically significant.
No serious safety events related to the vaccine have been confirmed and it was well tolerated across both dosing regimens, it said.
“This vaccine’s efficacy and safety confirm that it will be highly effective against COVID-19 and will have an immediate impact on this public health emergency,” Pascal Soriot, Astra’s chief executive, said in a statement.
The British drugmaker’s preliminary trial results mark a fresh breakthrough in the fight against a pandemic that has killed nearly 1.4 million people and roiled the global economy.
British Prime minister Boris Johnson said it was “incredibly exciting news the Oxford vaccine has proved so effective in trials.”
The interim analysis was based on 131 infections among participants who received the vaccine and those in a control group who were given an established meningitis shot.
The data showing a range of efficacy between 60% and 90% comes after US rivals published interim data in recent weeks showing efficacy of more than 90%.
While the efficacy reading from Astra’s viral vector vaccine is lower than its US rivals, the data will boost confidence about the chances of successfully developing a variety of vaccines using different approaches. Public health experts say the world will need many vaccines to meet global demand.
On Nov.16, US-based Moderna Inc said its experimental vaccine proved to be 94.5% effective based on an early data analysis.
A week earlier, Pfizer Inc and Germany’s BioNTech SE said their vaccine candidate had demonstrated greater than 90% efficacy that rose to 95% with analysis of full trial data.
Russia’s Sputnik-V vaccine on Nov.11 was also shown to be more than 90% effective, though only based on 20 infections.
The AstraZeneca vaccine uses a modified version of a chimpanzee common cold virus to deliver instructions to cells to fight the target virus, which is different than the new technology known as messenger RNA (mRNA) deployed by Pfizer/BioNTech and Moderna.
The company - one of the UK’s most valuable listed companies - will now immediately prepare regulatory submission of the data to authorities around the world that have a framework in place for conditional or early approval.
It will also seek an emergency use listing from the World Health Organization to speed up availability in low-income countries. In parallel, the full analysis of the interim results is being submitted for publication in a peer-reviewed journal.
Vaccine nationalism is a new concept in the current COVID-19 era, which is likely to hinder the global health and economic recovery causing more harm than the pandemic itself. Governments are scrambling to acquire vaccines for their populations
Across Britain, some people who have been counting down the days to their first COVID-19 jab are suddenly suffering doubts – among them my wife, Rachel, who was due to have it on Tuesday. The suspension of the roll out of the Oxford/AstraZeneca
AstraZeneca said an independent safety committee conducted a specific review of the blood clots in the US trial, as well as cerebral venous sinus thrombosis (CVST), which is an extremely rare blood clot in the brain, with the help of an independent neurologist.
The Ministry stressed in a statement on Thursday that its aim to continue expanding the scope of testing nationwide to facilitate the early detection of coronavirus cases and carry out the necessary treatment.
The UAE on Thursday sent a plane carrying 52 metric tons of food supplies to support Ukrainian refugees in the Republic of Bulgaria as part of the continuous relief provided by the UAE.
In a circular, the authority said that work for all federal ministries and entities will resume on Tuesday, 12th July.
The Ministry of Presidential Affairs shall provide the necessary support to the federal and local government agencies to implement the provisions of this resolution and the decisions required in this regard.