Louisville Mayor Greg Fischer said he was saddened by the violence.
One person died and another was injured in a shooting late on Saturday in Louisville, Kentucky's Jefferson Square Park, which has become a center for protests against the police killing of a Black woman in her home in March.
Reports of the shooting at the park came at 9pm (0100 GMT on Sunday), according to the Louisville Metro Police Department.
"Calls then came in that Sheriff's department personnel were in the park performing life-saving measures on a male who eventually died at the scene", the police said in a statement.
The statement said the police had cleared the park and homicide detectives were conducting an investigation. No further details were provided.
Louisville Mayor Greg Fischer said he was saddened by the violence that erupted at the site where people had gathered to voice concerns.
"It is a tragedy that this area of peaceful protest is now a crime scene", Fischer said in a tweet https://bit.ly/2VqRZrt.
The park has been a center for protests against the fatal shooting of Breonna Taylor, a Black woman killed in a hail of gunfire when drug investigators burst into her home in Louisville about three months ago.
Taylor, a 26-year-old emergency medical technician, was killed on March 13 after officers entered her apartment bearing a "no-knock" arrest warrant.
One of the three officers involved in her shooting was dismissed from the police department on Tuesday.
Taylor's slaying returned to prominence following the May 25 death of George Floyd, a Black man killed after a police officer knelt on his neck for nearly nine minutes while detaining him in Minneapolis.
The two incidents and others have become a rallying cry in nationwide protests against police brutality and racial bias in the US criminal justice system.
The area, set up as part of the nationwide protest movement following the death of unarmed African American George Floyd at the hands of a white police officer, has been a frequent target of Donald Trump.
If there was ever a moment when it seemed certain that the old American way of policing was dead, it came in early June with the drone footage of a river of tens of thousands of Black Lives Matter protesters
The violence occurred as hundreds of protesters marched for a third night in anger after Jacob Blake was seen in video being shot up to seven times at point-blank range by a white Kenosha police officer on Sunday.
The shooting Friday night was captured on video, and the state ACLU condemned what it described as a "horrific and deadly incident of police violence against a Black person.” Both the ACLU and the Southern Poverty Law Center quickly called for an investigation.
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