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The UN Office for the Coordination of Humanitarian Affairs (OCHA) said in its latest situation report that the humanitarian situation continued to deteriorate as a result of the "escalating" hostilities.
It said the attack occurred during a roadside security check in the region east of the Euphrates river in Syria, where Turkey carried out a military operation with allied Syrian rebels in October.
Around 900,000 people have been forced from their homes and shelters in less than three months, leaving huge numbers to sleep rough in the thick of winter.
Exhausted from days of driving in search of shelter in northwest Syria, 38-year-old Ghossoon has no idea where her family will go after fleeing regime and Russian bombardment.
Government forces, backed by Russian air power, have waged a major assault to capture the northwest province of Idlib, part of the last remaining territory held by rebels backed by Turkey.
The debut Mohammed Bin Rashid Al Maktoum Tolerance Award was presented to three individuals from different parts of the world recognising their outstanding efforts in strengthening the cause of humanitarianism at a glittering ceremony held in Dubai on Wednesday.
The United Nations warned on Friday fighting in northwest Syria could “end in a bloodbath” and it called again for a ceasefire, while Moscow denied reports of a mass flight of civilians from a Russian-led Syrian government offensive in the region.
Refugees in Turkey headed towards European frontiers on Friday after an official declared that borders had been thrown open, a response to the escalating war in Syria where 33 Turkish soldiers were killed by Russian-backed Syrian government troops.
According to the Syrian state news agency SANA one person was killed and three were injured. The explosion happened in the bus while it was near the entrance of a heavily fortified Republican Guards housing compound in the west of the Syrian capital, SANA said.
Military and security sources said that the army had seized a fuel storage tank hidden by black marketeers and was in the midst of handing out gasoline to residents when the explosion took place.