A rescuer works near a dead body in the rubble at the site of a heavily damaged residential building hit by a Russian missile in the town of Uman, Cherkasy region, Ukraine, on Friday. Reuters

The deadly new attacks included a strike on a residential block in the historic city of Uman in central Ukraine, where the media journalists saw rescue workers extracting victims' remains from a destroyed residential building.

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The barrage of almost two dozen missiles ended a weeks-long pause following the repeated Russian strikes that had aimed to paralyse Ukraine's energy grid during the winter months.

On Friday evening, workers in Uman, the site of an annual Hasidic pilgrimage, pulled the body of another child from under the rubble. Authorities said Russian cruise missiles killed 23 people — including four children — in Uman.

A Ukrainian soldier uses an anti-drone gun against a Russian drone in Donetsk, Ukraine, on Friday. AP

Earlier in the day, Dmitry, a 33-year-old resident from Lugansk, an eastern city under Russian control, was looking for his children.

"I want to see my children, they are under the rubble," he said.

Rescuers were using cranes to search for survivors among the remains of the multi-storey housing block in the city of 80,000 inhabitants.

"I've seen a lot, but I haven't lost my children before. Now I want to see my children, alive or dead," Dmitry said.

Local residents carry their belongings as they leave their home in Avdiivka, Donetsk, Ukraine, on Friday. AP

Russian missiles also hit the central city of Dnipro, already grief-stricken after a January strike on a tower block that killed more than 40 people.

Authorities said the strikes in Dnipro killed a 31-year-old woman and her two-year-old daughter while they slept.

The young woman's parents were hospitalised.

"Neighbours say that it was a quiet and kind family," regional authorities said.

Separately, authorities in the southern region of Kherson said on Friday evening that Russian forces shelled the village of Bilozerka, killing a 57-year-old woman and wounding another three people.

Ukrainian President Volodymyr Zelensky condemned the latest barrage and vowed a response.

A view shows smoke rising following an alleged drone attack in Sevastopol, Crimea, on Saturday. Reuters

"Only absolute evil can unleash such terror against Ukraine," he said in his evening address.

His advisor Mykhaylo Podolyak tweeted: "If you don't want THIS spread around the world, then give us weapons. Lots of weapons. And add sanctions."

Moscow said it had targeted reserve units of the Ukrainian military and that "all assigned objects were hit".

Moscow-installed officials in eastern Ukraine said Ukrainian shelling had killed nine people, including an eight-year-old girl in the city of Donetsk.